文献类型：期刊文献

英文题名：Cascade Access to Carboline Carboxylates from Indolyl Ketoximes and Acrylates via Palladium-Catalyzed C-H Bond Alkenylation/Annulation

作者：Fu, Xiao-Pan[1];Chen, Lu[1];Wu, Gao-Rong[1];Liu, Hong-Wei[1];Xia, Cheng-Cai[2,3];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shandong First Med Univ, Pharm Coll, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China;[3]Shandong Acad Med Sci, 619 Changcheng Rd, Tai An 271016, Shandong, Peoples R China

年份：2021

卷号：32

期号：01

起止页码：69

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000599193200011)，CCR-EXPANDED(收录号:WOS:000599193200011)】；

语种：英文

外文关键词：carboline carboxylates; alkenylation; annulation; indolyl ketoximes; C– H activation; palladium catalysis

摘要：An efficient palladium-catalyzed C-H bond alkenylation/annulation strategy to access carboline carboxylates from indolyl ketoximes and acrylates through C-C/C-N bond formation is reported. Indolyl ketoximes not only direct ortho -olefination with acrylates, but also undergo an intramolecular N-O bond cleavage/traceless annulation to construct carboline carboxylates straightforwardly in this concise method.