文献类型：期刊文献

英文题名：Poly(2-Oxazoline)-Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance

作者：Zhou, Min[1];Qian, Yuxin[1];Xie, Jiayang[1];Zhang, Wenjing[1];Jiang, Weinan[1];Xiao, Ximian[1];Chen, Sheng[1];Dai, Chengzhi[1];Cong, Zihao[1];Ji, Zhemin[1];Shao, Ning[1];Liu, Longqiang[1];Wu, Yuequn[1];Liu, Runhui[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Key Lab Ultrafine Mat, Minist Educ,Res Ctr Biomed Mat,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：59

期号：16

起止页码：6412

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20201608422536);WOS:【SCI-EXPANDED(收录号:WOS:000523764400011)】；

语种：英文

外文关键词：antibiotics; antimicrobials; drug design; peptides; polymers

摘要：Peptides have important biological functions. However, their susceptibility to proteolysis limits their applications. We demonstrated here for the first time, that poly(2-oxazoline) (POX) can work as a functional mimic of peptides. POX-based glycine pseudopeptides, a host defense peptide mimic, had potent activities against methicillin-resistant S. aureus, which causes formidable infections. The POX mimic showed potent activity against persisters that are highly resistant to antibiotics. S. aureus did not develop resistance to POX owning to the reactive oxygen species related antimicrobial mechanism. POX-treated S. aureus is sensitive to common antibiotics, demonstrating no observable antimicrobial pressure or cross-resistance in using antimicrobial POX. This study highlights POX as a new type of functional mimic of peptides and opens new avenues in designing and exploring peptide mimetics for biological functions and applications.