文献类型：期刊文献

英文题名：The degradation behavior of calcium-rich hydroxyapatite foams in vitro

作者：Zhang, Qinghao[1,2];Wang, Wenfu[2];Schmelzer, Eva[3];Gerlach, Jorg[3];Liu, Changsheng[1];Nettleship, Ian[2,3]

机构：[1]East China Univ Sci & Technol, Mat Sci & Engn Sch, Shanghai, Peoples R China;[2]Univ Pittsburgh, Dept Mech Engn & Mat Sci, Pittsburgh, PA USA;[3]Univ Pittsburgh, Dept Surg, McGowan Inst Regenerat Med, Pittsburgh, PA USA

年份：2021

卷号：109

期号：6

起止页码：859

外文期刊名：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

收录：;EI(收录号：20204009290946);WOS:【SCI-EXPANDED(收录号:WOS:000573707400001)】；

基金：National Institutes of Health, Grant/Award Number: R01HL108631; Shanghai Pujiang Program, Grant/Award Number: 18PJ1402400

语种：英文

外文关键词：degradation; hydroxyapatite scaffold; infiltration; in vitro culture; micro-CT

摘要：Hydroxyapatite (HA) is a well-known regenerative biomaterial. However, the slow degradation rate of HA is still an obstacle in clinical applications. In this study, we concentrated on investigating the degradation behavior of the calcium-rich HA foams, which had a demonstrated effect on blood differentiation in previous studies. The HA foams were processed by an emulsion method and were infiltrated with calcium nitrate to create a calcium carbonate second phase, heterogeneously distributed on and under the surface of the foam. During the 28-day solubility test, the calcium carbonate phase contributed to enhanced Ca(2+)ion release into the saline compared to phase pure HA foams. Both types of foams were biocompatible as demonstrated by human endothelial cell culture on their surface. The release of calcium ions, the degradation behavior, and the endothelial cell differentiation behavior suggest this biphasic ceramic is a candidate for bone marrow in vitro culture and a possible bone substitute material.