文献类型：期刊文献

英文题名：Studies on Re-188 Labeling and In Vivo Distribution of Magnetic Nanoparticles with Different Morphologies and Sizes

作者：Huang, Xiaocui[1];Zhao, Bo[2];Yang, Yuxiang[1];Yuan, Hongming[3];Yao, Pingping[1];Carlini, Riccardo[4];Huang, Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Navy Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai, Peoples R China;[3]Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China;[4]LAS Klee Barabino, Chem & Mat Chem Dept, I-16146 Genoa, Italy

年份：2024

卷号：34

期号：1

起止页码：346

外文期刊名：JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS

收录：;EI(收录号：20233414620872);WOS:【SCI-EXPANDED(收录号:WOS:001060153000001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant Nos. 20577010, 20971043), and the Open Project Program of State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University.

语种：英文

外文关键词：Magnetic core-shell nanoparticle materials; Re-188 radionuclide; Shape and size of nanoparticles; Biodistribution; Magnetic properties

摘要：There has been few research on the affect and distribution of different shapes of nanoparticles inside an organism during extraction and drug targeting. In order to obtain the distribution of magnetic nanoparticles with different morphology and size in vivo, a general method of Re-188 labeled Magnetic Core-Shell Nanoparticles (MNPs) Materials was developed. Based on the prepared magnetic particles with three different morphologies and sizes, including 230 nm spherical Fe3O4@SiO2 particles (S-230), 100 nm spherical Fe3O4@SiO2 particles (S-100) and peanut shaped Fe3O4@SiO2 particles (P-180, the length of the short axis is about 100 nm and the length of the long axis is about 180 nm), the aminated MNPs were labeled with radionuclide Re-188 through the coupling of diethylenetriamine pentaacetic anhydride. The nuclide Re-188 was labeled to investigate their distribution behavior in mice. Most of the small-size particles S-100 can be separated from the capture of the endothelial reticular system and removed by renal metabolism. Most of the larger particles, S-230 and P-180, will be captured by the endothelial reticular system, and the nanoparticles P-180 with large aspect ratio are easier to be captured by the tissue in the spleen and enter the cells through endocytosis.