文献类型：期刊文献

英文题名：Fabrication of PLCL Block Polymer with Tunable Structure and Properties for Biomedical Application

作者：Luo, Chenmin[1];Liu, Shengyang[1];Luo, Wei[2];Wang, Jing[1];He, Hongyan[1];Chen, Can[1];Xiao, Lan[3,4];Liu, Changsheng[1,2];Li, Yulin[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Wenzhou Inst, Wenzhou 325000, Peoples R China;[3]Queensland Univ Technol QUT, Ctr Biomed Technol, Sch Mech Med & Proc Engn, 60 Musk Ave, Brisbane, Qld 4000, Australia;[4]Queensland Univ Technol QUT, Australia China Ctr Tissue Engn & Regenerat Med AC, 60 Musk Ave, Brisbane, Qld 4000, Australia

年份：2023

卷号：23

期号：4

外文期刊名：MACROMOLECULAR BIOSCIENCE

收录：;EI(收录号：20230613546920);WOS:【SCI-EXPANDED(收录号:WOS:000930657200001)】；

基金：The research was supported by National Key R&D Program of China (2018YFE0201500), National Natural Science Foundation of China (51973060), and National Natural Science Foundation of China for Innovative Research Groups (51621002).

语种：英文

外文关键词：biodegradable; block copolymers; definite compositions; poly( L-lactide-b-epsilon-caprolactone); pre-polymerization

摘要：Biodegradable materials are pivotal in the biomedical field, where how to precisely control their structure and performance is critical for their translational application. In this study, poly(L-lactide-b-is an element of-caprolactone) block copolymers (bPLCL) with well-defined segment structure are obtained by a first synthesis of poly(is an element of-caprolactone) soft block, followed by ring opening polymerization of lactide to form poly(L-lactide acid) hard block. The pre-polymerization allows for fabrication of bPLCL with the definite compositions of soft/hard segment while preserving the individual segment of their special soft or hard segment. These priorities make the bPLCL afford biodegradable polymer with better mechanical and biodegradable controllability than the random poly(L-lactide-co-is an element of-caprolactone) (rPLCL) synthesized via traditional one-pot polymerization. 10 mol% is an element of-caprolactone introduction can result in a formation of an elastic polymer with elongation at break of 286.15% +/- 55.23%. Also, bPLCL preserves the unique crystalline structure of the soft and hard segments to present a more sustainable biodegradability than the rPLCL. The combinative merits make the pre-polymerization technique a promising strategy for a scalable production of PLCL materials for potential biomedical application.