文献类型：期刊文献

英文题名：New Indolocarbazoles from a Mutant Strain of the Marine-Derived Actinomycete Streptomyces fradiae 007M135

作者：Fu, Peng[1];Zhuang, Yibin[1];Wang, Yi[1];Liu, Peipei[1];Qi, Xin[1];Gu, Kangbo[2];Zhang, Daojing[2];Zhu, Weiming[1]

机构：[1]Ocean Univ China, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2012

卷号：14

期号：24

起止页码：6194

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000312564500020)】；

基金：This work was supported by grants from the 973 Program of China (No. 2010CB833804), NSFC (Nos. 21172204, 30973680, and 30670219), 863 Program of China (Nos. 2012AA092104, 2011AA09070106, and SS2013AA090201), the Special Fund for Marine Scientific Research in the Public Interest of China (No. 2010418022-3), and from Innovation and Research Foundation of Ocean University of China (No. 201261002).

语种：英文

摘要：Fradcarbazoles A-C (1-3), three new indolocarbazoles, were isolated from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135. Their structures were established by spectroscopic analysis, quantum chemical calculation, CD spectra, and chemical transformation. Fradcarbazole A (1) possessed a unique skeleton consisting of a staurosporine core, a thiazole ring, and an indole fragment. Compounds 1-3 displayed significant cytotoxicity against HL-60, K562, A-549, and BEL-7402 cell lines and inhibitory effects on the kinase PKC-alpha. with IC50 values of 0.001-4.58 mu M.