文献类型：期刊文献

英文题名：Targeted carbon monoxide delivery combined with chemodynamic, chemotherapeutic and photothermal therapies for enhanced antitumor efficacy

作者：Liu, Jing[1];Tang, Qi[1];Wang, Yi[1];Zhang, Hai-Lin[1];Ren, Bing[1];Yang, Shi-Ping[2,3];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai Normal Univ, Key Lab Resource Chem, Minist Educ, Shanghai 200234, Peoples R China;[3]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2022

卷号：46

期号：18

起止页码：8413

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;EI(收录号：20221812059247);WOS:【SCI-EXPANDED(收录号:WOS:000782243300001)】；

基金：This study was financially supported by the National Nature Science Foundation of China (No. 21571062 to JGL), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, and the Fundamental Research Funds for the Central Universities (No. 222201717003).

语种：英文

外文关键词：Cell culture - Chemotherapy - Controlled drug delivery - Copper compounds - Diseases - Drug products - Infrared devices - Irradiation - Manganese compounds - Oxidation - Sulfur compounds - Targeted drug delivery

摘要：Traditional chemotherapy is considered an indispensable clinical treatment modality because of its high efficiency, but its effectiveness is hindered by its shortcomings such as high side effects, poor selectivity and multidrug resistance, which can be alleviated by combining with some emerging cancer treatment modalities. Herein a multifunctional nanoplatform HMCuS@DHA@PDA@MnCO@FA (HDPMF) was prepared, where polydopamine-coated hollow mesoporous copper sulfide (HMCuS@PDA) was taken as the carrier with its surface covalently functionalized by a carbon monoxide (CO) releasing molecule (MnCO) and folic acid (FA) directing group, and a chemotherapeutic drug dihydroartemisinin (DHA) was also loaded within its hollow cavity. HDPMF selectively targeted folate receptor (FR) overexpressed cancer cell lines to which DHA and CO were delivered in the tumor microenvironment (acidic with H2O2 overproduction) upon 808 nm near-infrared (NIR) light irradiation. Meanwhile, the HMCuS@PDA core endowed HDPMF with an obvious photothermal effect and the ability to trigger decomposition of overexpressed H2O2 through a Fenton-like reaction to generate highly toxic hydroxyl radical (OH) species. In vitro cytotoxicity evaluation disclosed that HDPMF showed prominent anticancer effects with a relatively low IC50 value (<15 mu g mL(-1)) under 808 nm NIR light irradiation, and it presented very low cytotoxicity toward normal cells under dark conditions. Thus, combined with gas therapy, photothermal therapy, chemodynamic therapy, and chemotherapy, the nanoplatform HDPMF may offer implications for effective multimodal antitumor therapies.