文献类型：期刊文献

英文题名：Overoxidized polypyrrole/multi-walled carbon nanotubes composite modified electrode for in vivo liquid chromatography-electrochemical detection of dopamine

作者：Wen, Jingxia[2];Zhou, Li[1];Jin, Litong[2];Cao, Xuni[1];Ye, Bang-Ce[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

年份：2009

卷号：877

期号：20-21

起止页码：1793

外文期刊名：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000267453800001)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 20627005 and 20805015), the Shanghai Science and Technology Committee (08PJ14040) and East China University of Science and Technology (No. YF0157110).

语种：英文

外文关键词：Multi-walled carbon nanotubes; Overoxidized polypyrrole; Chemically modified electrode; Dopamine

摘要：Overoxidized polypyrrole/multi-walled carbon nanotubes (OPPy/MWNTs) modified electrode has been developed for sensitively detecting dopamine (DA). OPPy films developed outside MWNTs might have a porous morphology. Thus, OPPy/MWNTs films developed by this method do not reject ascorbic acid (AA). However, OPPy/MWNTs modified electrode shows largely enhancing oxidative current responses of DA. When combined with liquid chromatography, it not only obtains a low detection limit of 7.5 x 10(-10) mol L(-1) for DA, but also improves the selectivity of DA detection. Mechanisms for the enhancement are also well discussed in this paper. with this approach, microdialysis has been employed for successful assessment of DA in rat striatum. (C) 2009 Published by Elsevier B.V.