文献类型：期刊文献

英文题名：The membrane-targeting mechanism of host defense peptides inspiring the design of polypeptide-conjugated gold nanoparticles exhibiting effective antibacterial activity against methicillin-resistant Staphylococcus aureus

作者：Zhang, Weiwei[1];Wu, Yueming[1];Liu, Longqiang[2];Xiao, Ximian[2];Cong, Zihao[2];Shao, Ning[2];Qiao, Zhongqian[2];Chen, Kang[2];Liu, Shiqi[2];Zhang, Haodong[2];Ji, Zhemin[2];Shao, Xiaoyan[3];Dai, Yidong[3];He, Hongyan[2];Xia, Jiang[4];Fei, Jian[5];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat,Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]Shanghai Ruijin Rehabil Hosp, Shanghai 200023, Peoples R China;[4]Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Gen Surg, Shanghai 200025, Peoples R China

年份：2021

卷号：9

期号：25

起止页码：5092

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20212710586591);WOS:【SCI-EXPANDED(收录号:WOS:000661479900001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 21861162010 and 22075078), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), the Key technology research on remote screening platform of thyroid nodules and robot-assisted diagnosis between benign and malignant lesions (No. YG2019ZDA17), the research program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (22221818014). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Ring opening polymerization - Synthesis (chemical) - Fiber optic sensors - Metal nanoparticles - Bacteria - Drug delivery

摘要：Multidrug-resistant bacterial infections are a grand challenge to global medical and health systems. Therefore, it is urgent to develop versatile antibacterial strategies that can combat bacterial resistance without displaying toxicity. Here, we synthesize antibacterial polypeptide-conjugated gold nanoparticles that exhibit potent antibacterial activities against clinically isolated multiple drug resistance Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus, and excellent in vitro and in vivo biocompatibility. The antibacterial mechanism study indicates that over-production of reactive oxygen species results in the killing of bacteria. The overall antibacterial performance of these polypeptide-conjugated gold nanoparticles and the convenient synthesis of these polypeptides via lithium hexamethyldisilazide-initiated fast ring-opening polymerization on alpha-amino acid N-carboxyanhydride imply the potential application of this strategy in treating bacterial infections.