文献类型：期刊文献

英文题名：Surface chemical bonding with poly(hexamethylene guanidine) for non-leaching antimicrobial poly(ethylene terephthalate)

作者：Cao, Wei[1];Wei, Dafu[1];Jiang, Yachao[1];Ye, Saijun[1];Zheng, Anna[1];Guan, Yong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2019

卷号：54

期号：3

起止页码：2699

外文期刊名：JOURNAL OF MATERIALS SCIENCE

收录：;EI(收录号：20183905878388);WOS:【SCI-EXPANDED(收录号:WOS:000450016100066)】；

基金：The authors thank the Key Laboratory of Advanced Polymer Materials of Shanghai (Grant No. ZD20170203) and Shanghai Leading Academic Discipline Project (B502) for funding this work.

语种：英文

外文关键词：Morphology - Chemical bonds - Leaching - Medical applications - Ethylene glycol - Hydrophilicity - Surface reactions - Escherichia coli - Polyethylene terephthalates

摘要：Many efforts have been devoted to developing functional poly(ethylene terephthalate) (PET) due to its special biomedical applications in surgical meshes, heart valves, vascular grafts, artificial ligaments, etc. However, for antimicrobial PET the release of antimicrobial component remains a concern. In this work, an antimicrobial compound with terminal epoxy group was synthesized by ethylene glycol diglycidyl ether (EGDE) and polyhexamethylene guanidine hydrochloride (PHMG). Then, EGDE-PHMG was chemically bonded with PET surface through a reaction between the epoxy group of EGDE-PHMG and the amino group of aminated PET to generate non-leaching and permanent antimicrobial PET. The content of PHMG on PET surface, morphology and hydrophilicity of surface, antimicrobial activity and mechanical property of PET were investigated. The amount of EGDE-PHMG on PET surface reached at 3.96nmol/cm(2), resulting in excellent antimicrobial activities against Escherichia coli and Staphylococcus aureus with above 99.99% of inhibition rates. Due to the good hydrophilicity, excellent antimicrobial property, non-leaching characteristic of antimicrobial component and good mechanical properties, the as-prepared antimicrobial PET was promising in the biomedical applications.