文献类型：期刊文献

英文题名：Effects of a Coating of Nano Silicon Nitride on Porous Polyetheretherketone on Behaviors of MC3T3-E1 Cells in Vitro and Vascularization and Osteogenesis in Vivo

作者：Dai, Yong[1,5];Chu, Linyang[2,4];Luo, Zhengliang[1];Tang, Tingting[2];Wu, Han[3];Wang, Fan[3];Mei, Shiqi[3];Wei, Jie[3];Wang, Xuehong[3];Shang, Xifu[4]

机构：[1]Shandong Univ, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants,Dept Orthopae, 115 Jinzun Rd, Shanghai 200125, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[4]Univ Sci & Technol China, Affiliated Hosp 1, Dept Orthopaed Surg, Div Life Sci & Med, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China;[5]Third Peoples Hosp Hefei, Dept Orthopaed, 204 East Wangjiang Rd, Hefei 230022, Anhui, Peoples R China

年份：2019

卷号：5

期号：12

起止页码：6425

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20194707708607);WOS:【SCI-EXPANDED(收录号:WOS:000502193400010)】；

基金：This research was financially supported by the National Natural Science Foundation of China (nos. 81771990 and 51772194), the Shanghai Science and Technology Development Fund (nos. 15441902500 and 18DZ2291200), and the Opening program of Shanghai Key Laboratory of Orthopaedic Implants (no. KFKT2018003).

语种：英文

外文关键词：silicon nitride; polyetheretherketone; suspension coating; cellular responses; vascularization; osteogenic activity

摘要：To improve the bioperformances of porous polyetheretherketone (PPK) for bone repair, silicon nitride-coated PPK (CSNPPK) was prepared by a method of suspension coating and melt binding. The results revealed that, as compared with PPK, the surface roughness, compressive strength, and water absorption of CSNPPK increased, while the pore size and porosity of CSNPPK exhibited no obvious changes. In addition, the cellular responses (including attachment, proliferation, and differentiation as well as osteogenically related gene expressions) of the MC3T3-E1 cells to CSNPPK were remarkably promoted compared with PPK and dense polyetheretherketone in vitro. Moreover, in the model of rabbit femoral condyle defects, the results of micro computed tomography and histological and mechanical evaluation revealed that the ingrowth of new vessels and bone tissues into CSNPPK was significantly greater than that into PPK in vivo. Furthermore, the load-displacement and push-out loads for CSNPPK with bone tissues were higher than for PPK, indicating good osseointegration. In short, CSNPPK not only promoted vascularization but also enhanced osteogenesis as well as osseointegration in vivo. Therefore, it can be suggested that CSNPPK with good biocompatibility, osteogenic activity, and vascularization might be a promising candidate as an implant for bone substitute and repair.