文献类型：期刊文献

英文题名：A novel injectable starch-based tissue adhesive for hemostasis

作者：Cui, Ruihua[1];Chen, Fangping[1,2];Zhao, Yujiao[1];Huang, Wenjie[1];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2020

卷号：8

期号：36

起止页码：8282

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20204009300117);WOS:【SCI-EXPANDED(收录号:WOS:000572109900010)】；

基金：This investigation was supported by National Key Research and Development Program of China (No. 2016YFC1102900), National Natural Science Foundation of China (No. 51772100), Shanghai Science and Technology Agriculture Project (No. 202002080002F01474) and Joint Fund for equipment pre-research of the Ministry of Education (6141A02022618).

语种：英文

外文关键词：Amines - Starch - Swelling - Biodegradability - Tissue - Adhesives - Biomechanics - Sol-gels - Tissue engineering

摘要：Hemorrhage remains one of the direct causes of high mortality. The development of ideal hemostatic materials with sound ability to deal with severe wound is urgent needed. Although starch-based hemostatic powder has been widely used, hydrous physiological environments severely hamper its binding to the target tissue, thereby limiting the effectiveness in hemostasis. Herein, inspired by mussel adhesive protein, a novel injectable tissue-adhesive hydrogel (St-Dopa hydrogel) composed of starch, succinic anhydride and dopamine was developedin situby enzymatic crosslinking. The results show that St-Dopa hydrogels were intimately integrated with biological tissue and formed robust barriers to reduce blood loss. St-Dopa hydrogels exhibited superior capacity forin vitroandin vivohemostasis as compared with chitin hydrogels. In addition to the ease of operation, St-Dopa hydrogels exhibited rapid sol-gel transition, porous microscopic morphology, good swelling ratio and biodegradability, tissue-like elastomeric mechanical properties and excellent cyto/hemo-compatibility. These results suggest that this newly developed St-Dopa hydrogel is a promising biological adhesive and hemostatic material.