文献类型：期刊文献

英文题名：Copper-Doped Nano Laponite Coating on Poly(butylene Succinate) Scaffold with Antibacterial Properties and Cytocompatibility for Biomedical Application

作者：Tang, Xiaoming[1];Dai, Jian[1];Sun, Hailang[1];Saha, Nabanita[2];Saha, Petr[2];Tang, Liangchen[3];Cheng, Qilin[3];Wang, Deqiang[3];Wei, Jie[3]

机构：[1]Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Orthoped, Huaian 223001, Jiangsu, Peoples R China;[2]Tomas Bata Univ Zlin, Univ Inst, Ctr Polymer Syst, Tr T Bati 5678, Zlin 76001, Zlin, Czech Republic;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2018

卷号：2018

外文期刊名：JOURNAL OF NANOMATERIALS

收录：;EI(收录号：20191006604959);WOS:【SCI-EXPANDED(收录号:WOS:000454808200001)】；

基金：The grants were from the National Natural Science Foundation of China (51772194 and 81771990), Key Medical Program of Science and Technology Development of Shanghai (17441900600, 15441902500), and the Ministry of Education, Youth and Sports of the Czech Republic Program NPU I (LO1504).

语种：英文

外文关键词：Bone - Butenes - Scaffolds (biology) - Coatings - Morphology - Phosphatases - Stem cells - Amines - Cell culture

摘要：An ideal artificial bone will likely be multifunctional, combining different technologies to simultaneously promote bone regeneration while inhibiting microbial infection. In this study, copper- (Cu-) doped nano laponite (cnLAP) was prepared by a cation-exchanged method, and the cnLAP coating on poly(butylene succinate) (PBSu) scaffold was fabricated by poly(dopamine) modification. The results showed that incorporation of Cu ions into nano laponite (nLAP) did not have obvious effects on the morphology and surface area of cnLAP (compared with nLAP), which could be coated easily on macroporous PBSu scaffolds. In addition, the cnLAP-coated PBSu scaffolds could inhibit the growth of both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), indicating good antibacterial activity. Moreover, the cnLAP-coated PBSu scaffolds significantly promoted proliferation and improved alkaline phosphatase (ALP) activity of bone mesenchymal stem cells (BMSCs) compared with PBSu scaffolds. Furthermore, no obvious differences in cell responses to cnLAP- and nLAP-coated PBSu scaffolds were found, indicating that incorporation of Cu into nLAP had no negative effects on its cytocompatibility. The results suggested that the cnLAP-coated PBSu scaffolds exhibited excellent cytocompatibility and antimicrobial activity, which might offer promising opportunities for promoting bone regeneration and prevention of infectious from bacteria and effective treatment of bone defects.