文献类型：期刊文献

中文题名：双噁唑啉接枝的氨基酸聚合物作为手性催化中心在不对称Henry反应中的应用

英文题名：Application of Bisoxazoline-grafted Amino Acid Polymer as Chiral Catalytic Center in Asymmetric Henry Reaction

作者：朱佶鹏[1];刘润辉[2,3,4];宋恭华[1]

机构：[1]华东理工大学药学院,上海200237;[2]生物反应器工程国家重点实验室,上海200237;[3]材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237;[4]华东理工大学深圳研究院,深圳518063

年份：2023

卷号：44

期号：4

起止页码：163

中文期刊名：高等学校化学学报

外文期刊名：Chemical Journal of Chinese Universities

收录：CSTPCD;;EI(收录号：20232214153621);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000970935000004)】；北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：Supported by the Fundamental Research Funds for the Central Universities, China and the Free Exploring Basic Research Project at Shenzhen Research Institute of East China University of Science and Technology(No.2021Szvup042).

语种：中文

中文关键词：氨基酸聚合物;双噁唑啉;Henry反应;不对称催化

外文关键词：Amino acid polymer;Bisoxazoline;Henry reaction;Asymmetric catalysis

摘要：通过控制聚合单体L-谷氨酸-γ-乙酯和DL-半胱氨酸以及聚合过程中引发剂与单体的比例,制备了一系列溶解性能不同的氨基酸聚合物.利用其作为负载手性配体的载体,通过双噁唑啉配体上的双键和聚合物上巯基的加成反应,合成了一系列双噁唑啉接枝氨基酸聚合物.将合成的聚合物作为可回收的手性催化剂用于催化不对称Henry反应,反应选择性(e.e.值)在50%~90%之间,产率在67%~95%之间.该催化剂可以循环使用至少7次而不需要经过重新活化.
A series of amino acid polymers with different solubility was prepared through controlling the ratio of L-Glutamic acid-1-ethyl ester to DL-cysteine and the ratio of initiator to monomer in the polymerization process.With the amino acicl polymer as carriers for chiral ligands,a series of bisoxazoline-grafted amino acid polymers was synthesized by the addition reaction between the double bond on the bisoxazoline ligand and the sulfhydryl group on the polymer.The polymers can be used as a recoverable chiral ligand to catalyze asymmetric Henry reaction.The enantiomeric excess(e.e.)value of the reaction is between 50%—90%and the yield is between 67%—95%.The catalyst can be recycled for at least 7 times without reactivation.