文献类型：期刊文献

中文题名：介孔生物玻璃/磷酸钙骨水泥多级孔复合支架的制备及其载药特性研究

英文题名：Preparation of Hierarchically Porous MBG/CPC Scaffold and Its Performance on Drug Loading and Release

作者：丁峰[1];李楠[1];李永生[1];施剑林[1,2]

机构：[1]华东理工大学材料科学与工程学院,上海200237;[2]中国科学院上海硅酸盐研究所,上海200050

年份：2013

卷号：28

期号：1

起止页码：97

中文期刊名：无机材料学报

外文期刊名：Journal of Inorganic Materials

收录：CSTPCD;;EI(收录号：20131016087470);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000317589200015)】；北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：国家重大科学研究计划(2012CB933602)~~

语种：中文

中文关键词：离心法;介孔/大孔;复合支架;药物装载;缓释

外文关键词：centrifuging; mesoporous/macroporous; composite scaffold; drug loading; sustained release

摘要：采用离心法将介孔生物活性玻璃(MBG)和磷酸钙骨水泥(CPC)高效复合制备出介孔/大孔多级孔复合支架材料,评价了其对抗癌药物阿霉素的装载及释放性能。实验结果表明,采用离心法能在大孔支架CPC内有效负载大量的介孔生物活性玻璃,使其比表面积高达100.1 m2/g,负载量达47.2%,而采用传统浸渍法则不能将MBG粉体材料负载于CPC支架上。载药实验发现离心法制备的介孔/大孔复合支架对阿霉素的装载量达到了46 mg/g,是普通大孔CPC支架的11.5倍,且在体外具有药物缓释的特性。
Hierarchically composite scaffold （MBG/CPC） was successfully prepared by loading of mesoporous bioactive glasses （MBG） into macroporous calcium phosphate cement （CPC） with simply centrifuging method. It is revealed that MBG loading capacity on CPC and the BET surface area of MBG/CPC can reach 47.2% and 100.1 m^2/g, respectively. In contrast, almost no MBG loading is detected by using traditional impregnation route. Drug loading and releasing tests show that DOX loading capacity on hierarchically composite scaffold MBG/CPC is 46 mg/g, which is 11.5 times of that on pure CPC. Importantly, a sustained drug release in vitro performance is presented on MBG/CPC.