文献类型：期刊文献

英文题名：Bioinspired, Injectable, Quaternized Hydroxyethyl Cellulose Composite Hydrogel Coordinated by Mesocellular Silica Foam for Rapid, Noncompressible Hemostasis and Wound Healing

作者：Wang, Chengwei[1,2,3];Niu, Haoyi[1,2];Ma, Xiaoyu[1,2];Hong, Hua[1,2];Yuan, Yuan[1,2];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Shanghai Wego Biol Technol Co Ltd, Shanghai 200237, Peoples R China

年份：2019

卷号：11

期号：38

起止页码：34595

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20194207543500);WOS:【SCI-EXPANDED(收录号:WOS:000488322900005)】；

基金：This study was jointly supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), Joint project of Ministry of Education (6141A02022628), and Science and Technology Commission Shanghai Municipality (16441902800). The authors gratefully acknowledge the Leading Talents in Shanghai in 2017.

语种：英文

外文关键词：hydroxyethyl cellulose; mesocellular foam; hemostasis; antibacterial; wound healing

摘要：Massive bleeding control and anti-infection are the major challenges for urgent trauma with deep and noncompressible hemorrhage in both clinic and battlefield. Inspired by the coordinated primarily blood clot formation and secondly coagulation cascade activation in natural hemostasis process, an injectable, quaternized hydroxyethyl cellulose/ mesocellular silica foam (MCF) hydrogel sponge (QHM) for both hemorrhage control and antibacterial activities were prepared via one-pot radical graft copolymerization. The as prepared QHMs exhibited instant water-triggered expansion and superabsorbent capacity and thereby effectively facilitated blood components concentration. Moreover, the QHM1 with appropriate amount of MCF (9.82 w/w %) could further activate the coagulation factors. Synergistically, the QHM1 could reduce the plasma clotting time to 59 +/- 4% in vitro and showed less blood loss than commercially available hemostatics in vivo noncompressible hemorrhage models of lethal rabbit- liver defect. Furthermore, the QHM with a quaternary ammonium groups density of 2.732 mmol/g exhibited remarkable antibacterial activities and excellent cytocompatibility. With the efficient hemostasis efficacy and excellent antibacterial behavior, QHM dramatically facilitated the wound healing in a full-thickness skin defect model in vivo. Thus, this QHM represents a promising hemostatic in more widespread clinical application.