文献类型：期刊文献

中文题名：Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration

作者：Shi Liu[1];Zhengzhe Han[2];Ji-Na Hao[1];Dapeng Zhang[1];Xianglong Li[1];Yuanyuan Cao[1];Jinghuan Huang[2];Yongsheng Li[1,3]

机构：[1]Lab of Low-Dimensional Materials Chemistry,Key Laboratory for Ultrafine Materials of Ministry of Education,Frontier Science Center of the Materials Biology and Dynamic Chemistry,Shanghai Engineering Research Center of Hierarchical Nanomaterials,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237,China;[2]Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,600 Yishan Road,Shanghai,200233,PR China;[3]Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan,School of Chemistry and Chemical Engineering,Shihezi University,Shihezi,832003,China

年份：2023

期号：8

起止页码：1

中文期刊名：Bioactive Materials

外文期刊名：生物活性材料（英文）

收录：Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Key Research and Development Program of China(Grant No.2022YFC2403203);the National Natural Science Foundation of China(Nos.51972112,82202695,and 52172279);Basic Research Program of Shanghai(21JC1406003 and 19JC1411700);Leading Talents in Shanghai in 2018,Shanghai Rising Star Program(21QA1402200);the Natural Science Foundation of Shanghai(21ZR1416600);the 111 project(B14018).

语种：英文

中文关键词：Parathyroid hormone;Dual-mode release;Thermosensitive hydrogel;Angiogenesis;Bone regeneration

摘要：Osteogenesis,osteoclastogenesis,and angiogenesis play crucial roles in bone regeneration.Parathyroid hormone(PTH),an FDA-approved drug with pro-osteogenic,pro-osteoclastogenic and proangiogenic capabilities,has been employed for clinical osteoporosis treatment through systemic intermittent administration.However,the successful application of PTH for local bone defect repair generally requires the incorporation and delivery by appropriate carriers.Though several scaffolds have been developed to deliver PTH,they suffer from the weaknesses such as uncontrollable PTH release,insufficient porous structure and low mechanical strength.Herein,a novel kind of NIR-activable scaffold(CBP/MBGS/PTHrP-2)with dual-mode PTHrP-2(a PTH derivative)release capability is developed to synergistically promote osteogenesis and angiogenesis for high-efficacy bone regeneration,which is fabricated by integrating the PTHrP-2-loaded hierarchically mesoporous bioactive glass(MBG)into the N-hydroxymethylacrylamide-modified,photothermal agent-doped,poly(N-isopropylacrylamide)-based thermosensitive hydrogels through assembly process.Upon on/off NIR irradiation,the thermoresponsive hydrogel gating undergoes a reversible phase transition to allow the precise control of on-demand pulsatile and long-term slow release of PTHrP-2 from MBG mesopores.Such NIR-activated dual-mode delivery of PTHrP-2 by this scaffold enables a well-maintained PTHrP-2 concentration at the bone defect sites to continually stimulate vascularization and promote osteoblasts to facilitate and accelerate bone remodeling.In vivo experiments confirm the significant improvement of bone reparative effect on critical-size femoral defects of rats.This work paves an avenue for the development of novel dual-mode delivery systems for effective bone regeneration.