文献类型：期刊文献

英文题名：Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

作者：Wu, Zhaoying[1];Li, Quan[2];Pan, Yongkang[1];Yao, Yuan[1];Tang, Songchao[1];Su, Jiacan[2];Shin, Jung-Woog[3];Wei, Jie[1];Zhao, Jun[4,5]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed Trauma, Shanghai, Peoples R China;[3]Inje Univ, Dept Biomed Engn, Gimhae, South Korea;[4]Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Orthodont, Shanghai, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Shanghai Key Lab Stomatol,Shanghai Res Inst Stoma, Shanghai, Peoples R China

年份：2017

卷号：12

起止页码：3637

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000401003100003)】；

基金：The grants were from the Major International Joint Research Project between China and Korea (81461148033), the National Research Foundation of Korea (NRF) Grant (NRF-2014K2A2A7066637) and the National Natural Science Foundation of China (51502340, 81200815 and 81271705).

语种：英文

外文关键词：nanocomposite; degradability; apatite mineralization; cell behaviors; drug release

摘要：Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting-particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu composite (MPC) scaffold. In addition, the NMPC scaffold showed improved apatite mineralization ability, indicating better bioactivity, as the NMPC containing nanoporosity could induce more apatite and homogeneous apatite layer on the surfaces than MPC scaffold. The attachment and proliferation of MC3T3-E1 cells on NMPC scaffold increased significantly compared with MPC scaffold, and the alkaline phosphatase (ALP) activity of the cells on NMPC scaffold was expressed at considerably higher levels compared with MPC scaffold. Moreover, NMPC scaffold with nanoporosity not only had large drug loading (vancomycin) but also exhibited drug sustained release. The results suggested that the incorporation of NMS into PBSu could produce bioactive composite scaffold with nanoporosity, which could enhance water absorption, degradability, apatite mineralization and drug sustained release and promote cell responses.