文献类型：期刊文献

中文题名：Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

英文题名：Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

作者：Haiyang Sun[1];Hui Li[1];Jiayi Wang[1];Gonghua Song[1]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology

年份：2018

卷号：29

期号：6

起止页码：977

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2017_2018】；

基金：financially supported by the National Natural Science Foundation of China (No. 21572060)

语种：英文

中文关键词：5-HT;Barettin;Nature product;Nematicidal activity;Piperazinedione derivatives

外文关键词：5-HT;Barettin;Nature product;Nematicidal activity;Piperazinedione derivatives

摘要：Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita（M. incognita）. While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 mmol/L.
Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita（M. incognita）. While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 mmol/L.