文献类型：期刊文献

英文题名：Visible light controls cell adhesion on a photoswitchable biointerface

作者：Ming, Zunzhen[1];Hua, Xin[1];Xue, Yuan[1];Lin, Qiuning[1];Bao, Chunyan[1];Zhu, Linyong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：169

起止页码：41

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20182005183341);WOS:【SCI-EXPANDED(收录号:WOS:000440119200005)】；

基金：This work was supported by the National Natural Science Foundation of China (21472044, 51273064, 21425311), and The Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning.

语种：英文

外文关键词：Self-assembled monolayer; Photoswitch; Visible light response; Cell adhesion; Surface regeneration

摘要：Bioactive surfaces with specific interactions with cells have been greatly interested due to their potential applications in biosensors and tissue engineering. Herein, we fabricated a dopamine contained photo switch molecule (compound 1) which could form self-assembled monolayer (SAM) on substrates. The SAM showed a good photoswitch ability and manifested excellent fatigue resistance, which displayed its potential application as a biologically friendly surface coating. Contact angle analysis and cell experiments exhibited that the SAM surface was hydrophobic before irradiation which favored cell adhesion, while, it turned hydrophilic and induced cell unfouling or detachment after light irradiation. The uses of visible light stimulation (lambda(ex) = 530 nm) and the reversible regulation on cell adhesion and detachment should open up new avenues for bioacitve surfaces in biomedical applications. (C) 2018 Elsevier B.V. All rights reserved.