文献类型：期刊文献

英文题名：Enzyme-photo-coupled catalysis in gas-sprayed microdroplets

作者：Bai, Yunxiu[1];Luan, Pengqian[2];Bai, Yunpeng[3];Zare, Richard N.[4];Ge, Jun[1,2,5]

机构：[1]Tsinghua Univ, Dept Chem Engn, Minist Educ, Key Lab Ind Biocatalysis, Beijing 100084, Peoples R China;[2]Shenzhen Bay Lab, Inst Biomed Hlth Technol & Engn, Shenzhen 518107, Peoples R China;[3]East China Univ Sci & Technol ECUST, Shanghai Collaborat Innovat Ctr Biomfg, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Stanford Univ, Dept Chem, Stanford, CA 94305 USA;[5]Tsinghua Shenzhen Int Grad Sch, Inst Biopharmaceut & Hlth Engn, Shenzhen 518055, Peoples R China

年份：2022

卷号：13

期号：28

起止页码：8341

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20222812346215);WOS:【SCI-EXPANDED(收录号:WOS:000818030500001)】；

基金：This work was supported by the National Key Research and Development Program of China (2021YFC2102800). R. N. Z. thanks the US Air Force Office of Scientific Research through the Multidisciplinary University Research Initiative (MURI) program (AFOSR FA9550-21-1-0170).

语种：英文

外文关键词：Energy utilization - Enzyme activity - Large scale systems - Solar energy

摘要：Enzyme-photo-coupled catalysis produces fine chemicals by combining the high selectivity of an enzyme with the green energy input of sunlight. Operating a large-scale system, however, remains challenging because of the significant loss of enzyme activity caused by continuous illumination and the difficulty in utilizing solar energy with high efficiency at large scale. We present a large-scale enzyme-photo-coupled catalysis system based on gas-sprayed microdroplets. By this means, we demonstrate a 43.6-71.5 times improvement of solar energy utilization over that using a traditional bulk processing system. Owing to the improved enzyme activity in microdroplets, we show that chiral alcohols can be produced with up to a 2.2-fold increase in the reaction rate and a 5.6-fold increase in final product concentration.