文献类型：期刊文献

英文题名：Photo-Responsive Hydrogel for Contactless Dressing Change to Attenuate Secondary Damage and Promote Diabetic Wound Healing

作者：Li, Zi-Yuan[1,2];Zhang, Xiao-Jie[3];Gao, Yi-Ming[3];Song, Yanyan[1,2];Sands, Mia X.[4];Zhou, Shuang-Bai[3];Li, Qing-Feng[3];Zhang, Junji[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, Frontiers Sci Ctr Materiobiol & Dynam Chem,Inst Fi, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, Frontiers Sci Ctr Materiobiol & Dynam Chem,Inst Fi, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai 200011, Peoples R China;[4]Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

年份：2023

卷号：12

期号：17

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20231313794236);WOS:【SCI-EXPANDED(收录号:WOS:000947283000001)】；

基金：Z.-Y.L., X.-J.Z., Y.-M.G. contributed equally to this work. The authors acknowledge the financial support from the NSFC (22122803, 22105070, 81971848, 81620108019), Shanghai Sailing Program (20YF1410300 to Z.L.) and China Postdoctoral Science Foundation (2020M671017 to Z.L.). The project was supported by the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03), the Fundamental Research Funds for the Central Universities (222201717003), and the Clinical Research Plan of SHDC (SHDC2020CR1019B). The authors also thank Timothy Sands for helping polish the language together.

语种：英文

外文关键词：chronic wounds; dressing materials; photo-responsiveness; secondary damage; trauma reconstruction

摘要：Dressing change is a significant and inevitable process during wound healing. Possible secondary damage caused through dressing removal may impose a great threat on wound recovery, thus resulting in healing delays and ultimately a higher cost of hospitalization. Hence, a non-contact refreshable dressing with an ease of operation is of great desire, especially for chronic wounds where a long-term and repeated dressing change would be performed. Herein, an all-light-operated hydrogel dressing that would achieve a fast and remote-controllable dressing change (30 s for gelation/4 min for dissolution upon light irradiation) for chronic wounds is presented. In a diabetic murine model, substantially improved wound healing within 2-3 weeks is observed due to attenuated secondary damage during repeated dressing changes. Moreover, a promising facilitation of the healing processes of epithelialization, collagen deposition, cell proliferation, and inflammatory regulation is also detected, representing a synergistic effect of the photo-responsive hydrogel dressing for therapeutic efficiency.