文献类型：期刊文献

英文题名：An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation

作者：Wang, Yuwei[1,2];Liao, Jinghan[3];Lyu, Yanting[1,2];Guo, Qianqian[3];Zhu, Zhirong[1,2];Wu, Xupeng[1,2];Yu, Jiahong[1,2];Wang, Qi[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem,Sch Che, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Renji Hosp, Sch Biomed Engn, State Key Lab Oncogenes & Related Genes, Shanghai 200030, Peoples R China

年份：2023

卷号：33

期号：33

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20231714022094);WOS:【SCI-EXPANDED(收录号:WOS:000975310900001)】；

基金：Y.W. and J.L. contributed equally to this work. This work was supported by the National Key Research and Development Program of China (2021YFA0910000), NSFC Science Center Program (21788102), NSFC/China (22222803, 91959202 and 21974047), and Shanghai Municipal Science and Technology Major Project (2018SHZDZX03). All of the animal experimental procedures were performed according to the protocols approved by the Animal Care and Use Committee of the Shanghai Cancer Institute (license no. SYXK (Hu)2017-0011).

语种：英文

外文关键词：aggregation-induced emission; bacterial elimination; photodynamic therapy; tumor ablation; type I photosensitizer

摘要：Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on the biological microenvironment because it is difficult to produce type I and type II reactive oxygen species (ROS) simultaneously. Herein, an electron-rich anion-pi(+) AIEgen Pys-QM-TT is reported, which is capable of highly generating type I and type II ROS and realizing near-infrared fluorescence imaging synchronously. In the rational design of AIE photosensitizer, the strong electron-donating triphenylamine unit, pi-bridge thiophene and electron-withdrawing pyridinium salt unit can enhance the D-pi-A behavior, thereby improving the intramolecular charge transfer effect and extending the wavelength. Meanwhile, the powerful D-pi-A effect is supposed to reduce increment ES-T and promote the intersystem crossing processes, thus increasing the generation of ROS. In addition, the negatively charged anion in pyridinium salt group provides an electron-rich environment for the excited photosensitizer, so as to promote electron transfer to generate type I ROS. Therefore, Pys-QM-TT can not only generate type I and type II ROS simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections and ablate tumor tissue by promoting tumor cell apoptosis, inhibiting tumor cell proliferation and anti-angiogenesis.