文献类型：期刊文献

英文题名：Formal (4+2) cycloaddition of azoalkenes with trifluoromethylimidoyl sulfoxonium ylides: synthesis of trifluoromethyl pyridazine derivatives

作者：Wang, Jie[1];Wang, Shan-Shan[1];Xiao, Jun[1];He, Yu-Jie[1];Wu, Xin-Yan[1];Li, Xingguang[1];Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2023

卷号：59

期号：83

起止页码：12495

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20234414994557);WOS:【SCI-EXPANDED(收录号:WOS:001083532600001)，CCR-EXPANDED(收录号:WOS:001080278600001)】；

语种：英文

摘要：CF3-substituted imidoyl sulfoxonium ylides (TFISYs) are extraordinarily versatile and powerful synthons for use in cyclization chemistry that affords diverse CF3-substituted N-heterocycles. We first reacted TFISYs as a two-atom synthon with readily available azoalkenes and then subjected the products to metal-free formal (4+2) cycloaddition chemistry. This protocol features mild conditions and broad substrate scope, is simple to operate, and provides highly functionalized trifluoromethylpyridazines that are widely found in bioactive molecules. A transition-metal-free formal (4+2) cycloaddition of azoalkenes with trifluoromethylimidoyl sulfoxonium ylides has been achieved to afford trifluoromethylpyridazines.