文献类型：期刊文献

英文题名：Construction of α,α-disubstituted α-Amino Acid Derivatives via aza-Morita-Baylis-Hillman Reactions of 2-Aminoacrylates with Activated Olefins

作者：Gui, Hou-Ze[1,2];Jangra, Harish[5];Mao, Ben[1,2];Wang, Tian-Yu[1,2];Yi, Heng[1,2];Xu, Qin[1,2];Wei, Yin[3];Zipse, Hendrik[5];Shi, Min[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Meilong Rd 130, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Linglin Lu, Shanghai 200032, Peoples R China;[4]Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518000, Guangdong, Peoples R China;[5]LMU Munchen, Dept Chem, Butenandtstr 5-13, D-81377 Munich, Germany

年份：2020

卷号：12

期号：4

起止页码：1143

外文期刊名：CHEMCATCHEM

收录：;EI(收录号：20200608139568);WOS:【SCI-EXPANDED(收录号:WOS:000510555600001)】；

基金：We are grateful for the financial support from the National Basic Research Program of China [(973)-2015CB856603], the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000) and sioczz201808, the National Natural Science Foundation of China (21572052, 21421091, 21772226, 21772037 and 21861132014) and the Shenzhen Nobel Prize Scientists Laboratory Project and the Fundamental Research Funds for the Central Universities 222201717003.

语种：英文

外文关键词：phosphine catalysis; aza-MBH reaction; alpha,alpha-disubstituted; alpha-amino acids; methyl anion affinity values

摘要：A useful and convenient strategy for the synthesis of alpha,alpha-disubstituted alpha-amino acid (alpha-AA) derivatives via aza-Morita-Baylis-Hillman reaction of 2-aminoacrylates with activated olefins has been developed. A variety of alpha-AA derivatives containing an alpha-amino tertiary center were synthesized in good to excellent yields. The kinetic profiles and calculated methyl anion affinity (MAA) values were employed to rationalize the reactivities of different Michael acceptors used in the reaction.