文献类型：期刊文献

英文题名：An "AND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

作者：Wang, Wenli[1,2];Chen, Junwei[1,2];Ma, Huijuan[1,2];Xing, Wanjin[1,2];Lv, Nan[1,2];Zhang, Baoning[1,2];Xu, Huan[1,2];Wang, Wei[1,2,3,4];Lou, Kaiyan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA;[4]Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA

年份：2021

卷号：57

期号：66

起止页码：8166

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20213410802740);WOS:【SCI-EXPANDED(收录号:WOS:000677764800001)】；

语种：英文

外文关键词：Fluorescence - Probes - Computer circuits - Macrophages

摘要：An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.