文献类型：期刊文献

英文题名：Microstructure study of liposomes decorated by hydrophobic magnetic nanoparticles

作者：Qiu, Dan[1];An, Xueqin[1];Chen, Zhiyun[1];Ma, Xingyuan[1]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2012

卷号：165

期号：5

起止页码：563

外文期刊名：CHEMISTRY AND PHYSICS OF LIPIDS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000308681700007)】；

基金：This work is financially supported by the National Nature Science Foundation of China (20673059, 20573056 and 21073063), and Nature Science Keystone Foundation of Shanghai (08jc1408100), the National High-Tech Research and Development Plan of China ("863" plan, No. 2011AA06A107) and the Fundamental Research Funds for the Central Universities, China (No. WK0913002).

语种：英文

外文关键词：Magnetoliposomes; Hydrophobic magnetic nanoparticles; Lipid bilayer; Morphology; Microstructure

摘要：Magnetoliposomes, consisting of liposomes and magnetic nanoparticles (MNPs), have been tailored as very promising delivery vehicles in biotechnology and biomedicine applications. In this paper, liposomes with hydrophobic MNPs were prepared. The hydrophobic MNPs were successfully embedded in the lipid bilayer, which was proved by the results obtained from transmission electron microscope, atomic force microscope, differential scanning calorimetry and steady state fluorescence measurements. Moreover, systematic researches were carried out to investigate the effects of hydrophobic MNPs concentration on the morphology and microstructure of liposomes. The results show that the lipid bilayer was saturated with the hydrophobic MNPs when the mass ratio of MNPs to lipid reached 0.002. (C) 2012 Elsevier Ireland Ltd. All rights reserved.