文献类型：期刊文献

英文题名：Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo

作者：Wang, Guan; Zhao, Jian; Liu, Jianwen; Huang, Yongping; Zhong, Jian-Jiang; Tang, Wen

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Minist Educ, Key Lab Microbial Metab, Shanghai 200240, Peoples R China

年份：2007

卷号：7

期号：6

起止页码：864

外文期刊名：INTERNATIONAL IMMUNOPHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000246818200016)】；

语种：英文

外文关键词：ganoderic acid Me; NK cells activity; IL-2; IFN-gamma; NF-kappa B; Lewis lung carcinoma

摘要：Ganoderic acid Me (GA-Me) is a lanostane triterpenoid purified from Ganoderma lucidum mycelia, one of the most widely used herbs for cancer treatment and prevention in east Asia. In the present study, it was demonstrated that GA-Me could inhibit both tumor growth and lung metastasis of Lewis lung carcinoma in C57BL/6 rnice. Compared with the control group, Natural Killer (NK) cells activity was significantly enhanced by intraperitoneal administration of GA-Me (28 mg/kg). Results of ELISA assay and RT-PCR showed that the expressions of Interleukin-2 (IL-2) and Interferon-gamma (IFN-gamma) were also increased (p<0.05). Additionally, the expression of Nuclear Factor-KB (NF-KB) was up-regulated after the treatment of GA-Me, which might be involved in the production of IL-2. In conclusion, the findings of this study implied that GA-Me could effectively inhibit tumor growth and lung metastasis through increasing immune function. (C) 2007 Elsevier B.V. All rights reserved.