文献类型：期刊文献

英文题名：Organocatalytic asymmetric synthesis of tetrahydrocarbazoles via an inverse-electron-demand Diels-Alder reaction of 2,3-indole-dienes with enals

作者：Gu, Bo-Qi;Yang, Wu-Lin[1];Wu, Shu-Xiao;Wang, Yan-Bing;Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：5

期号：23

起止页码：3430

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806150092);WOS:【SCI-EXPANDED(收录号:WOS:000450737800010)，CCR-EXPANDED(收录号:WOS:000450737800010)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21572053), the Fundamental Research Funds for the Central Universities, and the China Postdoctoral Science Foundation (No. 2018M632037).

语种：英文

外文关键词：Amines

摘要：A novel 2,3-indole-diene synthon was designed and synthesized, and was first applied to a stereoselective inverse-electron-demand Diels-Alder reaction to construct tetrahydrocarbazoles. In the presence of chiral secondary amines, a variety of enantioenriched, multifunctionalized tetrahydrocarbazole derivatives were obtained in good yields (up to 83%) with excellent stereoselectivities (up to >20:1 dr, 98% ee).