文献类型：期刊文献

英文题名：NIR-Activated "OFF/ON" Photodynamic Therapy by a Hybrid Nanoplatform with Upper Critical Solution Temperature Block Copolymers and Gold Nanorods

作者：Huang, Baoxuan[1];Tian, Jia[1];Jiang, Dawei[1];Gao, Yun[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：20

期号：10

起止页码：3873

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20194107511527);WOS:【SCI-EXPANDED(收录号:WOS:000490658900025)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 51803058, 21875063) and the Fundamental Research Funds for the Central Universities (No. 222201814018, 50321101917022).

语种：英文

外文关键词：Hydrogen bonds - Infrared devices - Photosensitizers - Plasmons - Gold - Polyethylene oxides - Porphyrins - Cancer cells - Polyethylene glycols - Quenching - Nanorods - Block copolymers - Diseases

摘要：Photodynamic therapy (PDT) is a promising treatment modality for cancer treatment owing to its minimally invasive nature and negligible drug resistance. However, the disadvantages of conventional photosensitizers including universal aggregation-caused quenching (ACQ) effect or nonselective activation are still major hurdles for PDT clinical application. Herein, a new strategy for flexible manipulating photosensitizers in effective quenching and quick recovery of photoactivation is presented by introducing porphyrin units into upper critical solution temperature (UCST) block copolymer decorated gold nanorods (AuNR-P(AAm-co-AN-co-TPP)-b-PEG). The UCST block copolymer can achieve a self-quenching effect to make the porphyrin photosensitizers in the "Off' state by pi-pi stacking and hydrogen bonding interactions at physiological temperature, which greatly minimizes the nonselective phototoxicity of the photosensitizers to meet the requirement of phototherapy protected from sunlight. After the immigration of AuNR-P(AAm-co-AN-co-TPP)-b-PEG nanoparticles into the tumor tissue and the internalization by cancer cells, the UCST polymer chains can be extended under the local heating of AuNRs by NIR light irradiation, and then porphyrin photosensitizers are turned "On" to dramatically boost the PDT efficiency. Therefore, the process of PDT could be well manipulated in the "Off/On" state by the hybrid nanoplatform with UCST block copolymers and AuNRs, which will open new horizons for clinical treatments of PDT.