文献类型：期刊文献

英文题名：Metal-free β,γ-C(sp3)-H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation

作者：Li, Zheyao[1,2];Zhang, Huiwen[1,2];Zhao, Lin[1,2];Ma, Yueyue[3];Wu, Qiufang[1,2];Ren, Haosong[1,2];Lin, Zhongren[1,2];Zheng, Jun[1,2];Yu, Xinhong[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Shanghai Key Lab New Drug Design,Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioengn Reactors, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, 100 West Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China

年份：2024

卷号：60

期号：26

起止页码：3579

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20241215755909);WOS:【SCI-EXPANDED(收录号:WOS:001182596000001)，CCR-EXPANDED(收录号:WOS:001182596000001)】；

基金：We thank the National Natural Science Foundation of China(21476078), and Science and Technology Commission of Shanghai Municipality (12431900902).

语种：英文

外文关键词：Addition reactions

摘要：A DMP-initiated metal-free effective beta,gamma-asymmetric spirocyclopropanation of propanols strategy using oxidative iminium activation is described. This process has been realized by a synergistic amine-catalyzed one-pot cascade oxidation-Michael addition cyclopropanation for "one-pot" access to various spirocyclopropyl propionaldehydes/propanols from diverse 3-arylpropanols and alpha-brominated active methylene compounds under mild conditions and with high enantioselectivity (ee up to >99%).