文献类型：期刊文献

英文题名：Solution-mediated polymorphic transformation of amorphous form to Form I of olmesartan medoxomil in methanol-water mixture solvents

作者：Qi, Ming-Hui[1];Chen, Wan-Shang[1];Zhou, Hui[1];Chen, Jing-Yan[1];Ren, Guo-Bin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China

年份：2017

卷号：52

期号：4

外文期刊名：CRYSTAL RESEARCH AND TECHNOLOGY

收录：;EI(收录号：20171703603987);WOS:【SCI-EXPANDED(收录号:WOS:000399944200010)】；

基金：This work was supported by National Natural Science Foundation of China (No. 21576080). The authors would like to thank Zhejiang Huahai Pharmaceutical Co., Ltd. (China) for supplying olmesartan medoxomil raw material and Professor Shi-Zhong Yang from State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology for the help on measuring viscosity and surface tension.

语种：英文

外文关键词：polymorph; SMPT; amorphous; kinetics; olmesartan medoxomil

摘要：The polymorphic transformation of amorphous form to Form I of olmesartan medoxomil, an angiotensin II receptor blocker, was studied in methanol-water mixture solvents, by monitoring and identifying the transformation process through on-line instrument and off-line methods. The process is controlled by the nucleation of Form I and the dissolution of amorphous form. Besides, effects of water content, temperature and additives on the transformation process were discussed, the transformation rate increases with decreasing water content and increasing temperature, and additives investigated in this work can inhibit the process to some extent.