文献类型：期刊文献

中文题名：一种强阴离子交换树脂的制备及用于蜂蜜中喹诺酮类药物的富集检测

英文题名：Synthesis of a Strong Anion-exchange Resin and Its Application in Enrichment and Determination of Quinolone Drugs in Honey

作者：张田丽[1];胡坪[1];曲芳慧[1];王月荣[1];章弘扬[1]

机构：[1]华东理工大学化学与分子工程学院上海市功能性材料化学重点实验室,上海200237

年份：2017

卷号：36

期号：2

起止页码：230

中文期刊名：分析测试学报

外文期刊名：Journal of Instrumental Analysis

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2017_2018】；

基金：国家自然科学基金项目(81202493)

语种：中文

中文关键词：强阴离子交换;三甲胺修饰;固相萃取;蜂蜜;喹诺酮类药物;HPLC分析

外文关键词：strong anion-exchange; trimethylamine modification; solid-phase extraction; honey; quinolone drugs; HPLC analysis

摘要：采用沉淀聚合法,合成了对氯甲基苯乙烯-二乙烯基苯共聚物(VBC-DVB),并通过与三甲胺修饰反应,获得了一种含季铵基团的强阴离子交换树脂(SAX)。表征结果显示,树脂是呈单分散形态的微球,平均粒径为(3.8±1.5)μm,且具有较高的离子交换容量(0.83 meq/g)及良好的选择性吸附性能,对5种喹诺酮类药物(诺氟沙星、环丙沙星、洛美沙星、加替沙星、司帕沙星)的饱和吸附容量明显高于同类型商品化Oasis MAX固相萃取柱。将其用于蜂蜜样品中5种喹诺酮药物的选择性富集和HPLC分析。结果显示,该方法在一定范围内线性关系良好(r2≥0.998 9),平均加标回收率为86.8%~120.3%,日内重复性RSD不大于7.0%,日间RSD不大于8.5%。研究结果表明,所制备的SAX材料可用于复杂基质中喹诺酮类药物残留的高效前处理分析。
The chloromethyl styrene-divinylbenzene copolymer（VBC-DVB） was synthesized by the precipitation polymerization. The strong anion-exchange resin（SAX） containing quaternary ammonium group was then functionalized with trimethylamine. The resulting resins were characterized in the form of monodisperse microspheres,with mean diameters of（3. 8 ± 1. 5） μm. The resin possessed a high ion-exchange capacity（0. 83 meq/g） and a good adsorption performance in selectivity,and its saturated adsorption capacities for five quinolone drugs（norfloxacin, ciprofloxacin, lomefloxacin,gatifloxacin,sparfloxacin） were higher than those of conventional commercially available Oasis MAX SPE sorbents. The resin was used for the selective extraction and HPLC analysis of five quinolone drugs in honey samples. The method showed a good linear relationship in the certain concentration with correlation coefficients（r^2） not less than 0. 998 9. The average spiked recoveries were between86. 8% and 120. 3%. The RSDs of intra-day and inter-day were not more than 7. 0% and 8. 5%,respectively. The results mentioned above indicated that the SAX material prepared was suitable for the efficient pretreatment of quinolone drug residues in complex matrices.