文献类型：期刊文献

英文题名：Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

作者：Wu, Yueming[1];Chen, Kang[2];Wang, Jiangzhou[2];Chen, Minzhang[2];Chen, Yuan[2];She, Yunrui[2];Yan, Zi[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China

年份：2023

卷号：141

外文期刊名：PROGRESS IN POLYMER SCIENCE

收录：;EI(收录号：20231714024337);WOS:【SCI-EXPANDED(收录号:WOS:000989683900001)】；

基金：This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) , the National Natural Science Foundation of China (No. 22075078 , 52203162 , 21861162010) , Program of Shanghai Academic/Technology Research Leader (20XD1421400) , China National Postdoctoral Program for Innovative Talents (BX20220108) , the China Postdoctoral Science Foundation (2021M701198) , Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) , Re- search Program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (JKD01211520) . The authors also thank Research Center of Analy- sis and Test of East China University of Science and Technology for the help on the characterization for studies reviewed in this manuscript.

语种：英文

外文关键词：Host defense peptides; Antimicrobial amino acid polymers; Antibiotic -resistant; Polymerization methodology; Antimicrobial drug candidates

摘要：Microbial infections endanger human health and life. Conventional antibiotics has saved countless human lives, however, is seriously challenged by the quick emergence of antibiotic-resistant pathogens. It is ur-gent to develop new types of antimicrobial agents to treat antibiotic-resistant microbial infections. Host defense peptides (HDPs) have broad-spectrum antimicrobial activity and low susceptibility to antimicro-bial resistance, therefore, have been actively studied to develop promising antimicrobial agents. However, natural HDPs are structurally unstable due to their easy hydrolysis by proteases. Sequence-defined pep-tides have been explored as HDP mimics and have proven as promising candidates of antimicrobial drugs. Nevertheless, preparation of these HDP-mimicking peptides by solid-phase synthesis is time-consuming, expensive, and difficult for large scale synthesis. Assisted by the development of polymerization chem-istry, polypeptides can be prepared in the form of amino acid polymers conveniently and at large scales using the polymerization strategy. Amino acid polymers, also known as poly(amino acid)s, have the same or similar backbone structure as natural peptides and have excellent biocompatibility. Several classes of such antimicrobial polymers have been explored as synthetic mimics of HDPs including alpha-amino acid polymers, beta-amino acid polymers, peptoid polymers, amino acid hybrid polymers, and peptide mimicking polymers such as poly(2-oxazoline)s. To tune the biological activities and obtain the optimal antimicrobial polymers, key structure characteristics of HDPs are involved and investigated such as positive charges and the hydrophobic/hydrophilic amphiphilic structure. In this review, we provide an overview of research in the last decade about the design of HDP-mimicking antimicrobial amino acid polymers and beyond, in-cluding positive charge, amphiphilic structure, chain length, end group, hydrophilicity, stereochemistry, secondary structure, topology, self-assembly and backbone structure, as well as the major applications of antimicrobial amino acid polymers. Finally, we provide a perspective on the comparison between antimi-crobial peptides and antimicrobial amino acid polymers, as well as some key challenges that still need to be addressed for possible clinical application of HDP-mimicking antimicrobial amino acid polymers.(c) 2023 Elsevier B.V. All rights reserved.