文献类型：期刊文献

英文题名：Dual-functional polyetheretherketone surface modification for regulating immunity and bone metabolism

作者：Huo, Shicheng[1];Wang, Fan[2];Lyu, Zhuocheng[1];Hong, Qimin[1];Nie, Bin'en[1];Wei, Jie[2];Wang, You[1];Zhang, Jue[1];Yue, Bing[1]

机构：[1]Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Bone & Joint Surg,Dept Orthoped, Shanghai 200127, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2021

卷号：426

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20212810609988);WOS:【SCI-EXPANDED(收录号:WOS:000713469700001)】；

基金：This work was supported by the National Key R&D Program of China [grant number 2016YFC1101802] , Youth Program of National Natural Science Foundation of China [grant number 81802177] , Shanghai Sailing Program [grant number 18YF1413600) ] , the Research and Development fund of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine [grant number PYIII-17-011] , and Na-tional Natural Science Foundation of China [grant number 81972086] .

语种：英文

外文关键词：Polyetheretherketone; A-485; Mesoporous bioactive glass; Osteointegration; Immunomodulation

摘要：Polyetheretherketone (PEEK) has gained increased attention as an orthopedic implant material in recent years. However, the adverse inflammatory and immunological reactions elicited by the PEEK surface result in inferior osteointegration and affect its clinical utility. To improve osseointegration and enhance the success rate of PEEK implants, the surface can be biofunctionalized to be immunomodulatory. Herein, A-485, a potent and selective catalytic inhibitor of p300/CBP, was loaded into mesoporous bioactive glass that had been immobilized on the PEEK surface, and the immunomodulatory capability and effects of the biofunctionalized PEEK implants on osteointegration were evaluated. In vitro, the biofunctionalized PEEK surface not only suppressed the acute inflammatory response of macrophages, but also inhibited bone resorption and promoted osteogenesis, indicating that it plays critical and complex roles in maintaining normal bone metabolism. Moreover, the biofunctionalized surface induced less fibrous capsule formation and exhibited superior osseointegration properties in vivo. The A485-loaded MBG-biofunctionalized PEEK surface attenuated inappropriately activated immune responses mediated by macrophages and subsequently inhibited osteoclastogenesis, promoting osteogenesis and yielding superior osseointegration. Therefore, these surface-biofunctionalized PEEK implants, which regulate both immunity and bone metabolism, demonstrate strong potential for clinical application as orthopedic implants.