文献类型：期刊文献

英文题名：Yeast Nanoparticle-powered Tumor Photodynamic-Immunotherapy

作者：Song, Anning[1];Wang, Yuwei[2,3];Xu, Jialu[1];Wang, Xiaoyu[1];Wu, Yi[1];Wang, Heng[1];Yao, Chenlu[1];Dai, Huaxing[1];Zhang, Yue[1];Wang, Qi[2,3];Wang, Chao[1]

机构：[1]Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Inst Fine Chem,Feringa Nobel Prize Scientist Joint, Shanghai 200237, Peoples R China

年份：2024

卷号：54

外文期刊名：NANO TODAY

收录：;EI(收录号：20240115306542);WOS:【SCI-EXPANDED(收录号:WOS:001142701000001)】；

基金：This work was supported by National Key Research and Development Program of China (Grant No. 2022YFB3808100) , National Natural Science Foundation of China (Grant No. 32371476 and 32022043, 31900988) , Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China (Grant No. 22KJA180003) . This work was partly supported by Collaborative Innovation Center of Suzhou Nano Science & Technology, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) , the 111 Project.r work was partly supported by Collaborative Innovation Center of Suz-hou Nano Science & Technology, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) , the 111 Project.

语种：英文

外文关键词：Yeast nanoparticles; AIE photosensitizer; Photodynamic-immunotherapy; Photodynamic therapy; AIE Photosensitizers; Cancer immunotherapy; Combination therapy

摘要：Photodynamic therapy (PDT) uses a combination of light and a photosensitizing agent to destroy cancerous cells. However, the PDT alone often insufficient to elicit an effective anti-tumor response due to various factors including insufficient ROS generation and the weak induced immune response. Here, we report yeast nanoparticles (YNPs) loaded with aggregation-induced emission (AIE) photosensitizer QMC12 (YNP-QMC) for enhanced photodynamic-immunotherapy in animal models. YNPs have a strong immune adjuvant effect which could significantly activate various APCs and reverse the immunosuppressive microenvironment at tumor and tumor-draining lymph nodes (TDLNs) sites. More importantly, YNP-QMC can be attached with tumor cell antigens released from dying cells after PDT. This antigen attached nanoparticle can efficiently migrate to tumordraining lymph nodes and activate an antigen-specific systemic antitumor immunity. In combination with antiPD-L1, this strategy could promote the elimination of primary tumors and inhibit the growth of distant tumors. Thus, our AIE photosensitizer and adjuvant YNP-powered PDT strategy provides a simple way to enhance efficacy of PDT.