文献类型：期刊文献

英文题名：Chitooligosaccahrides: Digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro

作者：Ji, Xiaoguo[1];Zhu, Liangliang[1];Chang, Kunlin[1];Zhang, Ran[1];Chen, Yijia[1];Yin, Hao[2];Jin, Jiayang[1];Zhao, Liming[1,3]

机构：[1]East China Univ Sci & Technol, R&D Ctr Separat & Extract Technol Fermentat Ind, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Chang Zheng Hosp, Organ Transplant Ctr, Shanghai 200003, Peoples R China;[3]Shanghai Collaborat Innovat Ctr Biomfg Technol SC, Shanghai 200237, Peoples R China

年份：2022

卷号：275

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20214111008515);WOS:【SCI-EXPANDED(收录号:WOS:000708752100004)】；

基金：This work was supported by the National Key R&D Program of China (2019YFD0901800) , the Open Project Funding of the State Key Labo-ratory of Bioreactor Engineering, ECUST (ZDXM2019) , the Fundamental Research Funds for the Central Universities, and the 111 Project (B18022) .

语种：英文

外文关键词：In vitro fermentation; Clostridium; Short-chain fatty acid; Metabolomic; Polymerization degree; Chitooligosaccharides

摘要：Consumption of chitooligosaccharides (COS) prevents intestinal microecological disorder. The mechanisms for the effects of different COS on the gut microbiota are currently unclear. This study examined the impact of COS with different degrees of polymerization (DPs) on the gut microbial community and metabolic profile. COS significantly promoted the growth of Bacteroidetes, and inhibited that of Proteobacteria, which were significantly correlated with DPs. COS3 and COS2 enriched the butyrate production in microbial communities composed of Clostridium and Parabacteroides. Microbial communities enriched by DPs 4-6 COS displayed increased diversity in differential metabolite function. Several biomarkers were distinguished significantly, including unsaturated fatty acids, bile acids, indoles and amines, which are mainly related to processes such as fatty acid synthesis and decomposition, bile acid modification, and tryptophan metabolism. The results display the relationship among COS structure-gut microbes-metabolomics, providing a new perspective for COS as a functional food to improve intestinal health.