文献类型：期刊文献

中文题名：含硫正离子聚类肽水凝胶的合成与性能

英文题名：Synthesis and Properties of Polypeptoid Hydrogels Containing Sulfonium Groups

作者：颜舒婷[1];姚远[1];陶鑫峰[1];林绍梁[1]

机构：[1]华东理工大学材料科学与工程学院,上海市先进聚合物材料重点实验室,上海200237

年份：2022

卷号：43

期号：11

起止页码：212

中文期刊名：高等学校化学学报

外文期刊名：Chemical Journal of Chinese Universities

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000891136100005)】；北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：Supported by the National Natural Science Foundation of China (Nos.21901073, 52073092), the Natural Science Foundation of Shanghai, China (No.19ZR1412100) and the"Chenguang Program"of Shanghai Education Development Foundation and Shanghai Municipal Education Commission, China (No.18CG32).

语种：中文

中文关键词：聚类肽;N-硫代羧酸酐;水凝胶;抗菌能力;硫正离子;

外文关键词：Polypeptoid;N-Thiocarboxyanhydride;Hydrogel;Antibacterial ability;Sulfonium;

摘要：通过伯胺引发肌氨酸-N-硫代羧酸酐(Sar-NTA)和N-烯丙基甘氨酸-N-硫代羧酸酐(NGA-NTA)的开环聚合制备了一种三嵌段聚类肽,即聚(N-烯丙基甘氨酸)-b-聚肌氨酸-b-聚(N-烯丙基甘氨酸)(PNAG-b-PSar-b-PNAG,简称PASA);然后通过PASA侧链上的烯丙基与3,6-二氧杂-1,8-辛烷二硫醇之间的巯-烯“点击”化学反应合成了不同肌氨酸(Sar)摩尔分数的聚类肽水凝胶(HG).巯-烯“点击”反应生成的大量硫醚基团可进一步与环氧化合物反应,在水凝胶的网络骨架中生成硫正离子,从而获得具有固有抗菌能力的含硫正离子聚类肽水凝胶(S+HG).S+HG具有优异的吸水能力,能够在1 min内达到吸水平衡,饱和溶胀率高达2024%.S+HG内部由大量规则的连续海绵孔状结构组成,能够承受一定的剪切、摩擦及挤压等外界应力.S+HG具有强效的广谱抗菌能力,对革兰氏阴性的大肠杆菌(E.coli)和革兰氏阳性的金黄色葡萄球菌(S.aureus)的抗菌率都在99.99%以上.
Triblock copolypeptoid poly(N-allylglycine)-b-polysarcosine-b-poly(N-allylglycine)(PASA)was prepared by primary amine-initiated controlled ring-opening polymerization of sarcosine N-thiocarboxyanhydride(Sar-NTA)and N-allylglycine N-thiocarboxyanhydride(NAG-NTA).Followed by cross-linking via thiol-ene click reaction between the allyl groups on the PASA side chains and thiols groups on 3,6-dioxa-1,8-octanedithiol,polypeptoid hydrogels(HG)with different molar fraction of sarcosine(Sar),HG-Sar49%and HG-Sar64%,were obtained.A large amount of thioether groups were formed through the thiol-ene click reaction,which could further react with epoxide compounds to generate sulfonium groups on the network of PASA hydrogels.Thus,sulfoniumcontaining polypeptoid hydrogels(S+HG)with intrinsic antibacterial properties were successfully prepared.S+HG showed fast and excellent water absorption ability,which reached the water absorption balance within 1 min and had a saturation swelling rate up to 2024%.S+HG was composed of regular continuous sponge-like structures,and could withstand certain external stresses such as shearing,friction and extrusion.S+HG exhibited strong broad-spectrum antibacterial ability,and the antibacterial rates against gram-negative Escherichia coli(E.coli)and gram-positive Staphylococcus aureus(S.aureus)were over 99.99%.