文献类型：期刊文献

英文题名：Interlayer-Confined sonocatalysis by a covalent organic framework induces PANoptosis for potent cancer immunotherapy

作者：Liu, Shuning[1];Cheng, Xuan[1];Zhang, Run[1];Li, Jiale[2];Li, Xingguang[2];Xiang, Huijing[1]

机构：[1]Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2026

卷号：99

外文期刊名：MATERIALS TODAY

收录：;EI(收录号：20263221265158);Scopus(收录号：2-s2.0-105046609769);WOS:【SCI-EXPANDED(收录号:WOS:001847595700001)】；

基金：The authors greatly acknowledge the final support of the National Natural Science Foundation of China (Grant No. T2322018, T2522014, 22571083, 22201073, and 32501191) , Shanghai Shuguang Program (No. 25SG41) , Fundamental Research Funds for the Central Universities, Natural Science Foundation of Shanghai Municipality (Grant No. 25ZR1402145) , and China Postdoctoral Science Foundation (Grant No. 2025 M772879) .

语种：英文

外文关键词：Covalent Organic Frameworks; Interlayer Synergy; Reactive Oxygen Species; PANoptosis; Cancer Immunotherapy

摘要：The efficacy of cancer immunotherapy is often compromised by the immunosuppressive tumor microenvironment and resistance to single-cell-death pathways. Here, we report a lamellar covalent organic framework (DAQCOF-O) that enables interlayer-confined sonocatalysis to trigger PANoptosis for potent cancer immunotherapy. By engineering ordered C=O active sites within a crystalline, layered architecture, DAQ-COF-O achieves an interlayer spacing of similar to 0.34 nm, which confines peroxymonosulfate activation under ultrasound excitation. This confinement facilitates the rapid dimerization of SO5 center dot- radicals, generating a potent, localized storm of reactive oxygen species. The resulting oxidative stress simultaneously activates pyroptosis, apoptosis, and necroptosis through PANoptosome signaling, thereby bypassing conventional resistance mechanisms. ROS-driven immunogenic cell death releases damage-associated molecular patterns and autologous tumor antigens, which potently matures dendritic cells and primes cytotoxic T lymphocytes. In vivo, PEGylated DAQ-COF-O nanoparticles not only eradicate primary tumors but also induce abscopal effects that suppress distant tumors and completely inhibit pulmonary metastasis in murine models. Transcriptomic analysis confirms upregulation of PANoptosisrelated genes and immune activation pathways (e.g., antigen cross-presentation). This work introduces an interlayer-confined vaccinology paradigm that leverages programmable framework architecture for spatiotemporally controlled ROS generation, offering a transformative platform to overcome immune escape and metastasis in cancer immunotherapy.