文献类型：期刊文献

英文题名：Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing

作者：Wang, Fan[1];Wang, Mengyao[1];He, Qingsong[1];Wang, Xuehong[1];Sun, Ping[2];Ji, Yinjun[3];Niu, Yunfei[3];Li, Fengqian[2];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Eighth Peoples Hosp, Dept Orthopaed, Shanghai 200235, Peoples R China;[3]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China

年份：2023

卷号：133

起止页码：195

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20223012420383);WOS:【SCI-EXPANDED(收录号:WOS:000830904100002)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 32171340, 81772343 and 81771990) and the Key Medical Program of Science and Technology Development of Shanghai (No. 20S31900400) and the National Science Foundation of Shanghai (No. 21ZR1447900).

语种：英文

外文关键词：Black tantalic oxide; PEEK fibers; Artificial ligament; Photothermal antibacterial effects; Ligament-bone healing

摘要：Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament (ACL) reconstruction remains a significant challenge. In this study, black tantalic oxide (BTO) submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide (WTO) through magnesium thermal reduction (MTR) method, and BTO was coated on polyetheretherketone (PEEK) fibers (PKF), which were woven into fabrics (PBT) as artificial ligaments. PBT with BTO coating exhibited excellent photothermal performance, which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo . PBT with optimized surface properties (e.g., submicro-topography and hydrophilicity) not only significantly facilitated rat bone mesenchymal stem cells (BMSC) responses (e.g., proliferation and osteogenic differentiation) in vitro but also stimulated new bone formation for ligament-bone healing in vivo . The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect. In summary, BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection, thereby promoting ligament-bone healing. Therefore, PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction. (c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.