文献类型：期刊文献

英文题名：Gold(I)-Catalyzed Glycosylation with Glycosyl Ynenoates as Donors

作者：Li, Xiaona[1];Li, Chenyu[1];Liu, Rongkun[1];Wang, Jiazhe[1];Wang, Zixuan[1];Chen, Yan[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：21

期号：23

起止页码：9693

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000502163300086)，CCR-EXPANDED(收录号:WOS:000502163300086)】；

基金：Financial support from the National Thousand Young Talents Program (Y100-4Q-1701, YC0140103), the National Natural Science Foundation of China (21871081), and the Fundamental Research Funds for the Central Universities (50321031916002, 22221818014) is gratefully acknowledged.

语种：英文

摘要：A simple and versatile glycosylation method with both armed and disarmed glycosyl ynenoates as donors is developed. Employing a gold(I) complex as catalyst with or without the assistance of TfOH, the scope of the present glycosylation protocol is very wide. The utility of the present ynenoate donors is demonstrated in the efficient synthesis of oligosaccharides via the latent-active strategy and the multiple orthogonal one-pot strategy. Finally, this approach enables the formal synthesis of the tetrasaccharide hapten of Streptococcus pneumoniae serotype 3 and the highly convergent synthesis of the 32mer polymannoside.