文献类型：期刊文献

英文题名：Fabrication of hierarchically porous carbon networks for the electrochemical determination of superoxide anion released from living cells

作者：Gao, Qianmei[1];Zhao, Hongli[1];Wang, Zhenxing[1];Cai, Xuan[1];Zhou, Lifang[2];Lan, Minbo[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

年份：2021

卷号：330

外文期刊名：SENSORS AND ACTUATORS B-CHEMICAL

收录：;EI(收录号：20205209680747);WOS:【SCI-EXPANDED(收录号:WOS:000609441400002)】；

基金：This work was supported by the Natural Science Foundation of Shanghai (19ZR1412000), the Science and Technology Commission of Shanghai Municipality (STCSM,20520712500), and the Fundamental Research Funds for the Central Universities(50321102017022).

语种：英文

外文关键词：Non-enzymatic sensor; Superoxide anion; Hierarchically porous carbon nanomaterials; Living cells

摘要：Realizing the quantitative detection of superoxide anions (O-2(center dot-)) is of great significance to the pathological research based on the correlation between O-2(center dot-) and many diseases. Currently, the main challenge for O-2(center dot-) electrochemical detection in the actual sample is the development of effective nano-mimetic materials to replace natural enzymes to achieve high-selectivity detection of O-2(center dot-). In this work, hierarchically porous carbon networks (HPCN) were successfully prepared through 1,3,5-trimethylbenzene (TMB)-induced self-assembly and carbonization strategy. Owing to the introduction of TMB, HPCN obtains the changed morphology, enriched pore structure, and improved defect degree, which promotes mass transfer and leads to faster electron transfer efficiency. Therefore, the non-enzymatic O-2(center dot-) electrochemical sensor fabricated with HPCN (denoted as HPCN/SPCE) exhibits high sensitivity (607.4 mu A cm(-2) mM(-1)) and excellent selectivity for detecting O-2(center dot-). Importantly, the sensor successfully achieved the dynamic monitor of O-2(center dot-) released from living cells and has the potential to distinguish between cancer and normal cells.