文献类型：期刊文献

英文题名：Far-Red and Near-IR AIE-Active Fluorescent Organic Nanoprobes with Enhanced Tumor-Targeting Efficacy: Shape-Specific Effects

作者：Shao, Andong[1,2];Xie, Yongshu[1,2];Zhu, Shaojia[1,2];Guo, Zhiqian[1,2];Zhu, Shiqin[1,2];Guo, Jin[3];Shi, Ping[1,2];James, Tony D.[4];Tian, He[1,2];Zhu, Wei-Hong[1,2]

机构：[1]E China Univ Sci & Technol, Collaborat Innovat Ctr Coal Based Energy iCCE, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Collaborat Innovat Ctr Coal Based Energy iCCE, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem,Inst Fine Chem, Shanghai 200237, Peoples R China;[3]PerkinElmer Instruments Shanghai Co, Shanghai 201203, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2015

卷号：54

期号：25

起止页码：7275

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20152600964750);WOS:【SCI-EXPANDED(收录号:WOS:000356390300007)】；

基金：This work was supported by NSFC for Creative Research Groups (21421004) and Distinguished Young Scholars (21325625), National 973 Program (2013CB733700), NSFC/China, Oriental Scholarship, Shanghai Pujiang Program (13PJD010), Fok Ying Tong Education Foundation (142014), Fundamental Research Funds for the Central Universities (222201313010), and Catalysis and Sensing for our Environment (CASE) network. AIE = aggregation-induced emission.

语种：英文

外文关键词：aggregation-induced emission; fluorescent probes; morphology effects; near infrared; tumor targeting

摘要：The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.