文献类型：期刊文献

中文题名：线型-超支化结构两亲性嵌段聚合物mPEG-b-hPCL的合成、表征、自组装行为及体外释药行为的研究

英文题名：Synthesis and self-assembled behavior of amphiphilic block coplolymers mPEG-b-hPCL with linear-hyperbranched structure and their application in drug delivery

作者：张玺[1];肖艳[1];郎美东[1]

机构：[1]生物材料教育部重点实验室华东理工大学材料科学与工程学院,上海200237

年份：2014

卷号：42

期号：3

起止页码：118

中文期刊名：化工新型材料

外文期刊名：New Chemical Materials

收录：北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金：中央高校基本科研业务费专项基金项目(WD0913008,WD1014017);国家自然科学基金(51103041);上海市重点学科项目(B502);上海市重点实验室项目(08DZ2230500);教育部留学回国人员科研启动基金

语种：中文

中文关键词：聚己内酯;聚乙二醇;开环聚合;线型-超支化

外文关键词：poly（e-caplactone） （PCL）, polyethylene glycol（PEG）, ring opening polymerization（ROP）, linear-hy- perbranch

摘要：通过开环聚合、酯化反应等方法制备聚乙二醇-聚己内酯(PEG-b-hPCL)线性-超支化嵌段共聚物,利用核磁(1 H-NMR)、凝胶渗透色谱(GPC)等表征。DSC结果表明超支化PCL的熔程较长;测定临界胶束浓度(CMC),发现随着聚合物中PCL含量增加,胶束CMC下降;在水、甲醇中自组装,发现水中聚集体粒径为300nm左右,大于甲醇中的聚集体;通过透射电镜(TEM)发现水相聚集体为胶束,甲醇相聚集体为纳米颗粒。以吲哚美辛为药物,研究PEG-b-hPCL胶束的载药能力,其载药量在15%左右,包封率在33%左右,36h后累积释放量有所不同,较高PCL含量的胶束的药物释放量较少。
Linear-hyperbranched structure amphiphilic block coplolymers mPEG-b-hPCL were synthesized by ring opening polymerization（ROP）and esterification reaction, characterized by1H-NMR and GPC. DSC results showed that the copolymers had a long melting range between 30 ℃ and 50 ℃. Their critical micelle coneentrations（CMC）were reduced with the increase of PCL content. The eopolymers could formed micelles with hydrodynamic diameters around 300nm in wa- ter but smaller nanoparticles in methanol, confirmed by DLS and TEM. Morover, the mPEG-b-hPCL micelles were capable of encapsulating indometacin with a loading content of 15 w/w% and exhibiting controlled release of up to 40 % loaded drug over a time period of 36 h with higher PCL content.