文献类型：期刊文献

英文题名：Iron-Catalyzed C3-Formylation of Indoles with Formaldehyde and Aqueous Ammonia under Air

作者：Wang, Qing-Dong;Zhou, Bin;Yang, Jin-Ming[1];Fang, Dong;Ren, Jiangmeng;Zeng, Bu-Bing[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China; Yancheng Teachers Univ, Sch Pharm, Yancheng 224007, Jiangsu, Peoples R China

年份：2017

卷号：28

期号：19

起止页码：2670

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000418319600031)，CCR-EXPANDED(收录号:WOS:000418319600031)】；

基金：We thank the National High Technology Research and Development Program of China (2007AA02Z301), the Natural Science Foundation of Jiangsu Province (BK20141257), the Natural Science Foundation of Yancheng Teachers University (09YCKL021, 14YCKL001), and the Fundamental Research Funds for the Central University (WY111307) for their generous financial support

语种：英文

外文关键词：iron catalysis; formylation; indoles; indolecarbaldehydes; formaldehyde

摘要：An efficient iron-catalyzed C3-selective formylation of free (N-H) or N-substituted indoles was developed by employing formaldehyde and aqueous ammonia, with air as the oxidant. This new method gave 3-formylindoles in moderate to excellent yields with fairly short reaction times. Moreover, this procedure for catalytic formylation of indoles can be applied to gram-scale syntheses.