文献类型：期刊文献

英文题名：Tissue adhesive indocyanine green-locking granular gel-mediated photothermal therapy combined with checkpoint inhibitor for preventing postsurgical recurrence and metastasis of colorectal cancer

作者：Zeting, Yuan[1,2,3,4,5];Shuli, Ma[1,2,3,4];Yue, Li[1,2,3];Haowei, Fang[6];Jing, Shang[1,2,3,5];Yueping, Zhan[1,2,3];Jie, Wang[7];Teng, Chen[7];Wanli, Deng[8,9];Zhang, Kunxi[1,2,6,10,11];Peihao, Yin[1,2,4,7,10,11]

机构：[1]Shanghai Univ Tradit Chinese Med, Intervent Canc Inst Chinese Integrat Med, Shanghai, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Putuo Hosp, Shanghai, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Putuo Hosp, Cent Lab, Shanghai, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai, Peoples R China;[5]Anhui Med Univ, Shanghai Putuo Cent Sch Clin Med, Hefei, Peoples R China;[6]Shanghai Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai, Peoples R China;[7]Shanghai Univ Tradit Chinese Med, Dept Gen Surg, Putuo Hosp, Shanghai, Peoples R China;[8]Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Oncol, Shanghai, Peoples R China;[9]Shanghai Univ Tradit Chinese Med, Dept Oncol, Putuo Hosp, Shanghai 200060, Peoples R China;[10]Shanghai Univ Tradit Chinese Med, Intervent Canc Inst Chinese Integrat Med, Shanghai 200060, Peoples R China;[11]Shanghai Univ Tradit Chinese Med, Putuo Hosp, Shanghai 200060, Peoples R China

年份：2023

卷号：8

期号：6

外文期刊名：BIOENGINEERING & TRANSLATIONAL MEDICINE

收录：;EI(收录号：20233814749199);WOS:【SCI-EXPANDED(收录号:WOS:001068770700001)】；

基金：Clinical Specialized Discipline of Health System of Putuo District in Shanghai, Grant/ Award Number: 2021tszk01; Clinical Specialized Disease Construction Project of Shanghai Putuo District Municipal Health Commission, Grant/Award Number: 2019tszb01; Fifth Batch of "Xinglin Scholar" of Shanghai University of Traditional Chinese Medicine; National Natural Science Foundation of China, Grant/Award Numbers: 81973700, 51973108, 81973625; Shanghai Key Medical Specialty Construction Project, Grant/Award Number: ZK2019B18; The National Key Research and Development Program of China, Grant/Award Number: 2019YFC1316000; The Reserve Outstanding Chinese Medicine Talent of Shanghai University of Traditional Chinese Medicine; The Science and Technology Innovation Project of Shanghai Putuo District Health Commission, Grant/Award Number: ptkwws202004

语种：英文

外文关键词：colorectal cancer; granular hydrogel; ICG; immunotherapy; photothermal therapy

摘要：Developing effective therapy to inhibit postoperative recurrence and metastasis of colorectal cancer (CRC) is challenging and significant to reduce mortality and morbidity. Here, a granular hydrogel, assembled from gelatin microgels by dialdehyde starch and interpenetrated with in situ polymerized poly(sulfobetaine methacrylate-co-N-isopropylacrylamide) (P(SBMA-co-NIPAM)), is prepared to load and lock Food and Drug Administration (FDA)-approved indocyanine green (ICG) with definite photothermal function and biosafety for photothermal therapy (PTT) combining with checkpoint inhibitor. The presence of P(SBMA-co-NIPAM) endows granular hydrogel with high retention to water-soluble ICG, preventing easy diffusion and rapid scavenging of ICG. The ICG-locking granular hydrogel can be spread and adhered onto the surgery site at wet state in vivo, exerting a persistent and stable PTT effect. Combined with & alpha;PD-L1 treatment, ICG-locking granular hydrogel-mediated PTT can eradicate postsurgery residual and metastatic tumors, and prevent long-term tumor recurrence. Further mechanistic studies indicate that combination treatment effectively promotes dendritic cells maturation in lymph nodes, enhances the number and infiltration of CD8+ T and CD4+ T cells in tumor tissue, and improves memory T cell number in spleen, thus activating the antitumor immune response. Overall, ICG-locking gel-mediated PTT is expected to exhibit broad clinical applications in postoperative treatment of cancers, like CRC.