文献类型：期刊文献

英文题名：Ruthenium(II)-Catalyzed α-Fluoroalkenylation of Oxime Ethers with gem-Difluorostyrenes via C-H Activation and C-F Cleavage

作者：Zhang, Lili[1];Deng, Kezuan[1];Wu, Gaorong[1];Yang, Jinyue[1];Tang, Shibiao[1];Fu, Xiaopan[1];Xia, Chengcai[2];Ji, Yafei[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China;[2]Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Inst Pharmacol, Tai An 271016, Shandong, Peoples R China

年份：2020

卷号：85

期号：19

起止页码：12670

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20204509462652);WOS:【SCI-EXPANDED(收录号:WOS:000577156600056)，CCR-EXPANDED(收录号:WOS:000577156600056)】；

基金：We gratefully thank the National Natural Science Foundation of China (project no. 21676088) for financial support.

语种：英文

外文关键词：Catalysis - Ketones - Reaction intermediates - Ruthenium compounds - Activation analysis - Ethers

摘要：A novel route for ruthenium( II)-catalyzed afluoroalkenylation of oxime ethers with gem-difluorostyrenes via C-H activation and C-F cleavage has been developed for the first time. Notably, the alkenyl units of products exhibit exclusive Z-configuration. This reaction features a broad substrate scope and good functional group tolerance. A plausible reaction mechanism is confirmed by an available cycloruthenated intermediate. Besides, the O-methyl oximyl-directing group can be readily removed to access the alpha-fluoroalkenylated acetophenones.