文献类型：期刊文献

英文题名：Novel Deep Eutectic Solvent-Hydrogel Systems for Synergistic Transdermal Delivery of Chinese Herb Medicine and Local Treatments for Rheumatoid Arthritis

作者：Xiao, Suyun[1,2];Wang, Liyun[1,2];Han, Wei[3];Gu, Liyun[3];Cui, Xiuming[1,2];Wang, Chengxiao[1,2]

机构：[1]Kunming Univ Sci & Technol, Sch Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China;[2]Key Lab Sustainable Utilizat Panax Notoginseng Re, Kunming 650500, Yunnan, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2022

卷号：39

期号：10

起止页码：2431

外文期刊名：PHARMACEUTICAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000777364900001)】；

基金：This work was supported by the National Natural Science Foundation of China (81760642; 82060645), the Key Natural Science Foundation of Yunnan Province (202002AA100004-2, 202102AA310045, 202002AA1000056, and 202101AT070099). All authors declare no conflicts of interest.

语种：英文

外文关键词：chinese herb medicine; deep eutectic solvent; hydrogel; rheumatoid arthritis; transdermal drug delivery

摘要：In this study, a novel hydrogel system incorporating an amino acid-based deep eutectic solvent (DES) was prepared, and the skin-permeation enhancement of traditional Chinese herb medicine was evaluated using "sanwujiaowan" extract as the model formula. Briefly, a DES-extract complex was constructed by co-heating the herb formula extracts with the amino acid as the hydrogen receptor and citric acid as the hydrogen donor. The DES-extract complex demonstrated excellent dissolution and skin permeability of the complicated ingredients in the extracts. Consequently, the DES-extract complex was introduced to a hydrogel system, which showed better mechanical properties and viscoelasticity performance. Using a collagen-induced arthritis rat model, the DES-hydrogels exerted an enhanced therapeutic effect that significantly reduced the inflammatory response with systemic toxicity of the extracts. Therefore, our work suggests a novel strategy for synergistic transdermal delivery of Chinese herb medicine and local treatments for rheumatoid arthritis.