文献类型：期刊文献

英文题名：Cu-catalyzed mild and efficient oxidation of THbCs using air: application in practical total syntheses of perlolyrine and flazin

作者：Zheng, Bo[1];Trieu, Tien Ha[1];Meng, Tian-Zhuo[1];Lu, Xia[1];Dong, Jing[1];Zhang, Qiang[1];Shi, Xiao-Xin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：8

期号：13

起止页码：6834

外文期刊名：RSC ADVANCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000425508900012)】；

基金：We are grateful to the National Natural Science Foundation of China (No. 20972048) for the financial support of this work.

语种：英文

摘要：A mild, efficient and environmentally benign method for synthesis of aromatic beta-carbolines via Cu(II)-catalyzed oxidation of 1,2,3,4-tetrahydro-beta-carbolines (TH beta Cs) was developed, in which air (O-2) was used as the clean oxidant. This method has advantages such as environmentally friendliness, mildness, very good tolerance of functional groups, high yielding and easy experiment operation. In addition, this new methodology was successfully applied in the efficient and practical total syntheses of beta-carboline alkaloids perlolyrine and flazin.