文献类型：期刊文献

英文题名：Enhancement of the Water Affinity of Histidine by Zinc and Copper Ions

作者：Song, Yongshun[1];Zhan, Jing[2];Li, Minyue[2];Zhao, Hongwei[3,4];Shi, Guosheng[2];Wu, Minghong[2];Fang, Haiping[1,5]

机构：[1]East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Shanghai Appl Radiat Inst, Shanghai 200444, Peoples R China;[3]Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai 201210, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China;[5]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Peoples R China

年份：2022

卷号：23

期号：7

外文期刊名：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000781999000001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 11974366 and 62075225), the Fundamental Research Funds for the Central Universities, China, the National Science Fund for Outstanding Young Scholars (Grant No. 11722548), the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (No. QYZDJ-SSW-SLH053), and the National Defense Science and Technology Innovation Special Zone Project.

语种：英文

外文关键词：solubility; aromatic amino acids; cation-n interaction; transition-metal ions

摘要：Histidine (His) is widely involved in the structure and function of biomolecules. Transitionmetal ions, such as Zn2+ and Cu2+, widely exist in biological environments, and they are crucial to many life-sustaining physiological processes. Herein, by employing density function calculations, we theoretically show that the water affinity of His can be enhanced by the strong cation-pi interaction between His and Zn2+ and Cu2+. Further, the solubility of His is experimentally demonstrated to be greatly enhanced in ZnCl2 and CuCl2 solutions. The existence of cation-pi interaction is demonstrated by fluorescence, ultraviolet (UV) spectroscopy and nuclear magnetic resonance (NMR) experiments. These findings are of great importance for the bioavailability of aromatic drugs and provide new insight for understanding the physiological functions of transition metal ions.